This clinicians’ guide addresses one of the largest cultural groups in the United States today, persons of Latin American ancestry, commonly referred to as Latinos or Hispanics.¹ The guide considers suicide as part of social phenomena, but our attention will be to suicides and suicide attempts as deeply psychological, emotional events. The emphasis is on what drives some people to think about suicide, plan a suicide, and attempt suicide. This guide is intended for mental health professionals and other health providers dedicated to delivering services to the diverse Hispanic or Latino population. It discusses suicidal behavior, demographics of the Hispanic population, risks for suicide, and prevention, intervention, recovery, and postvention. The guide includes two case studies of suicide attempts by teenage girls and questions for clinicians to consider in the assessment and intervention.