This policy brief from the Rural and Underserved Health Research Center examines the receipt of treatment for major depression in non-metropolitan and metropolitan areas. Depression remains common, afflicting approximately 7% of both non-metropolitan and metropolitan areas. Receipt of treatment fell into two categories: use of prescription drugs or talking to a medical doctor or other professional about depressive feelings. Rates of using prescription medication and rates of visiting a general practice/family doctor were higher in non-metropolitan than metropolitan adults. A shortage of mental health specialists in non-metropolitan areas may partially explain the difference in treatment receipt.