Latinos experience similar rates of mental health distress as other groups. However, disparities exist in access to mental health services and the provision of culturally responsive mental health services. This desk reference was developed for mental health care professionals interested in learning how to integrate cultural traditions and beliefs to implement culturally centered interventions when working with Hispanic and Latinx populations, thus increasing equity and quality of services. The content derives from Module 4 of the Trainer’s Guide for Clinical Applications of Cultural Elements When Working with Hispanic and Latino Populations.