This guide was developed from a three-session learning community held for the Technology Transfer Centers in Summer 2022. The purpose of this guide is to demonstrate how TA purveyors can use D&I science findings, models, and frameworks to provide the most effective training and technical assistance to accelerate practice change. The guide includes real-world TA examples, exercises that can be used by TA purveyor teams to learn about how to apply D&I science to their work, and an implementation project template that helps a TA purveyor plan and track an intensive TA activity.