Drs. Keshavan and Yassine will provide a historical overview of psychiatric nosology, with a focus on the schizophrenia spectrum. Based on their findings and the synthesis of extant literature, they suggest that a feasible next step is to reframe mental disorders based on biology (biotypes) and etiology (etiotypes). They will outline the established etiological factors for psychosis including genetic and environmental factors such as trauma and substance abuse, and they will propose an innovative clustering approach of the psychosis spectrum based on etiology using machine learning. This approach aims to facilitate future efforts at targeted interventions, prevention, and policy changes. Finally, they will summarize by proposing a revised multiaxial classification of psychotic disorders, using the phenotype, biotype, and etiotype dimensions.

Presenters: Walid Yassine, DMSc, MMSc and Matcheri Keshavan, MD